Introduction: The Gen Mark eSensor XT8is a molecular diagnostic product used in the clinical hospital lab to determine apatient’s genetic propensity to metabolize the blood thinner, warfarin. It was commercialized in 2009 and was awarded theMDEA. ALine was honored as their supplier.
Challenges: GenMark needed a room temperature bonding methodfor the DNA chemistry on the sensor. To meet the requirementsfor 20 minute test results, the PCR amplified patient sample needed to be actively circulated onthe multiplexed sensor to ensure the binding kinetics were enhanced over simple static diffusion.
Solution: The laminate contains an on-board recirculating pump, which is mechanically actuated. Theuse of a room temperature bonding pressure sensitive adhesive permits room temperature bondingof both the injection molded and the PCB containing the sensor pads with the DNA Probe chemistry.
Summary: Our IPP approach offered GenMark the ability to quickly assess different laminate designs to get the required pumping performance. We changed the materials to improve bonding.Of great asset to the product development process was our ability to turn new designs in one day.
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