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ALine and Fralock form Strategic Alliance

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Fralock (Division of Lockwood Industries, Inc.) and ALine, Inc. have entered into a strategic alliance to address all phases of microfluidic consumable development.  Clients in the Diagnostic and Life Science markets will benefit from access to ALine’s engineering and rapid prototyping capabilities, while having access to Fralock’s manufacturing process engineering expertise, and supply chain management. Offering the two company’s complimentary skills and manufacturing resources enables a wider variety of tools and processes to be considered early in product development, lowering risk at scale-up, while operating in an FDA registered and ISO13485 environment. Both Fralock, and ALine are based in southern…

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Valves in Microfluidic Cartridges

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In a single-use cartridge for the point of care, why use pneumatic control of on-board diaphragm valves in the cartridge when a linear actuator against a flexible layer works just as well? This question was recently posed by a client as they consider their development path from proof of concept. They envision a couple of different product use environments, one involving a benchtop instrument, and another a portable handheld using battery power. In some cases, the answer might just boil down to personal preference. But from a development perspective,  pneumatically controlled on-board valves offer more flexibility in design of the cartridge….

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New Board of Directors

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I am very pleased to announce the appointment of four new members to the Board of Directors: Rob Randelman, Bruce Sargeant, Steve Schaefers, and Joe Stetter. Each person brings a valuable perspective to the board including FDA design control expertise, supply chain management, international business development, and world class scientific expertise in electrochemistry. Each member is distinguished in their respective careers and well regarded within the business communities they serve. Each has been involved in the growth of high tech businesses. Their combined expertise brings a unique strength to the board, and I feel very fortunate to have their support. Their breadth of…

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It’s a Materials World

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What happens between a surface and a fluid stream can lead to foul play. That’s why I’m a materials girl. The complex physics and chemistry of surfaces is an important consideration in any product development, and is particularly important for microfluidic systems where the high surface area to volume ‘concentrates’ the effect of the surface. The choice of materials should be taken into consideration during the early design of microfluidic devices to enable applications including cell culture, immunoassays, or nucleic acid amplification. With sophisticated workflows for immuno-analysis, materials impact assay sensitivity, limit of detection, fluid circuit functional performance, and shelf-life….

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A Systems Approach to Microfluidics Products

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One of the complexities of Microfluidics Product Development is the need to integrate the functional performance of a variety of dissimilar components. It involves a combination of science, engineering, and materials science to create a robust product solution. Ultimately, any product that performs tests and measurements is fundamentally an information producing system, and the quality of the information depends on how well each of it’s disparate components are harmonized to become ‘more than the sum of the parts’.






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Experts In the Science and Engineering of Microfluidics

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ALine’s expertise in microfluidics design and production, integrates custom fluid handling in a single-use device with semi-automated instrument control. Our toolbox of well characterized on-board valves, pumps, metering, mixing, and de-bubbling strategies perform robustly with manufacture scale up. Starting with an assay that is performed in a microtiter plate, ALine translates the manual workflow into a semi-automated process in a microfluidic device. In as little as 60 days, you can be running your target assay in a customized microfluidic device with automated control in an instrument, and begin optimizing the device design and reagents to achieve proof of principle..  

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3D Printed Microfluidic Connectors Solve the Chip-to-World Interface Problem

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3D printing lends itself to the manufacture of components which are tailored to specific needs of the end user. For example, an early application of 3D printers was in the manufacture of custom hearing aid shells, designed to fit comfortably into the ear of the individual patient. In dentistry, it has been used to create crowns, mouth guards and braces. Applications in the Life Sciences and Medical Device industry continue to grow as the print resolution, and available materials expand. Exotic applications in tissue engineering, with the goal of producing organs and tissues with defined composition, are being explored. For…

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ALine Is Growing!

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We are pleased to announce that Dr. Stefano Begolo, a recent post doctoral fellow in Rustem Ismagilov’s lab, is joining ALine, in early August 2015. Stefano was a customer while he was working on the Slip Chip technology at CalTech and he enjoyed interacting with us enough to be interested in being part of the team! Stefano’s expertise in microfluidics, his familiarity with assay development and PCR, and his interest in working on a variety of client programs will add tremendous depth to our offering. With his expertise in 3D printing, we plan to offer this capability along with our popular laminate…

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