Good Products are Built on Good Science and Engineering

Our technical articles describe and demonstrate the performance of our platform technology. Please use them as a guide to understand how to incorporate important functions such as metering, mixing, pumping, and fluid toggling in our platform technology.

We continue to enhance our capabilities and publish new articles to further support the use of Integrated Polymeric Platform (IPP) to meet your product performance requirements.

Developing Diagnostic Products Using Polymer Laminate Technology

This paper provides an overview of the platform that is typified by the use a rapid prototyping platform that incorporates a variety of materials to create functional and robust devices. The processes do not require tooling, and can be scaled for high volume roll to roll manufacture. Some case studies are explored.

ALine has developed robust cutting, cleaning, and assembly processes that produce high quality functional devices with a turnaround time of one week or less.

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Polymer Laminate Cell Culture Card Supports NASA’s Astrobionics Program

An early successful application of the fabrication platform was demonstrated with the NASA Astrobionics program. Our approach enabled the successful execution of an autonomous experiment in near earth orbit, demonstrating the robustness of our fabrication technology.

On board liquid storage for months, the mechanical stresses of launch, and fluid control in zero gravity. Even under these extreme conditions, our devices performed flawlessly.

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Modular Designs for Reproducible Performance of On-Board Pumps

Understanding the effects of stack tolerances is important for establishing design rules to ensure optimal performance over a wide range of conditions.

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It's a Materials World, and I'm a Materials Girl

What happens between a surface and a fluid stream can lead to foul play. The complex physics and chemistry of surfaces is an important consideration in any product development, and is particularly important for microfluidic systems where the high surface area to volume ‘concentrates’ the effect of the surface. The choice of materials should be taken into consideration during the early design of microfluidic devices to enable applications including cell culture, immunoassays, or nucleic acid amplification.

With sophisticated workflows for immuno-analysis, materials impact assay sensitivity, limit of detection,
fluid circuit functional performance, and shelf-life. This is because…

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Outsourcing Point of Care Diagnostic Development

The demand for rapid diagnostic analysis is putting pressure on companies to move testing out of central laboratories and into the point-of-care environment. According to Markets and Markets Inc.’s latest report, “This market (microfluidics) is mainly driven by the rising demand for point-of-care (POC) testing, increasing demand for microfluidic chip miniaturization as it offers lower testing time and improved portability, growing Asian market, rising incidences of lifestyle diseases, increasing R&D expenditure and healthcare spending, and growing stem cell and cancer research…In 2014, the in-vitro diagnostics application segment accounted for the largest share of the global microfluidics market.”

When testing is closer to the patient, turnaround time, sample touch time and logistics are all reduced. Rapid results improve patient care and outcomes, and reduce required blood and healthcare resources.

Hence, why has it taken so long for POC to be realized?

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Valve Performance and Operation

This recent paper details the use of different flexible membranes and their effect on valve performance. The use of Spike and Hold pneumatic actuation for long term valve actuation is also detailed.

This article requires a Non-Disclosure Agreement (NDA) in order to view. Please contact us to request the NDA.

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Metering and Mixing Evaluated in a Test Chip

In this paper we combine metering and mixing to demonstrate the effectiveness of a simple bellows to mix two fluid streams that are combined after being metered with on-board pumps.

This article requires a Non-Disclosure Agreement (NDA) in order to view. Please contact us to request the NDA.

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Effect of Channel Width on Air Bubbles and Strategies for Air Bubble Control

In this paper we evaluate the effect of channel width and height and describe optimal dimensions to minimize air bubble formation, as well as describing best strategies for metering and dispensing. We also describe strategies to mitigate air bubbles in our devices, especially during mixing.

This article requires a Non-Disclosure Agreement (NDA) in order to view. Please contact us to request the NDA.

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How to Design a Microfluidic Device - Part 1

To help folks who are simply users of microfluidics, yet are in charge of developing a microfluidic, we present here a four part series on the things one should consider before picking up the phone and talking to any of a number of service providers.

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How to Design a Microfluidic Device - Part 2

In Part 2 of this 4 part series, we discuss taking a modular approach to integrating the complete assay workflow in a microfluidic device, focusing on the importance of simplifying the assay protocol to ensure a robust and reliable microfluidic product.

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Proof of Principle to Product Launch

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