July 9, 2013 1:04 pm Published by Leave your thoughts
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Custom Protein sample cell designed for Cornell researchers combines improved through put with ease of use.

Small Angle X-Ray Scattering Cells

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An important and new technique in protein structure determination in solution is made possible with bio-molecular Small Angle X-Ray Scattering (BioSAXS). Its application is increasing exponentially, and provides a powerful tool which, when used in combination with other techniques, allows elucidation and correlation of the functional and structural domains of different classes of proteins and protein complexes in solution. The Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) is pioneering this technique.

The tedious task of filling and sealing precious samples of concentrated protein is simplified with an easy-to-use cell,pictured here, designed and developed by ALine in collaboration with Nozomi Ando, a graduate student in Sol Gruner’s group at Cornell University.

“We had wonderful results with the SAXS cells you recently designed with Nozomi Ando; a paper has already been published.” remarked Dr. Gillilan,staff scientist at the Cornell High Energy Synchrotron Source (MacCHESS) about the custom cells. He further noted, “Your adhesive laminate [used to bond the mica film] is the main reason the cells have worked so well for us.”

A thin sheet of mica is attached to either side by removing the liner covering the adhesive film on the top and bottom of the disk. The channel leading from the outer edge to the center is used for sample introduction, and the notches on either side facilitate insertion into the synchrotron.

You need to supply your own window material!These devices can be customized to meet your sampling needs. Contact us

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